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Studies: TB can be treated in few months

(Agencies)
Updated: 2007-09-19 06:52

CHICAGO - New research gives hope for successfully treating tuberculosis
in a few months rather than the six months or more currently needed to
beat the contagious lung disease, doctors reported Tuesday.

Adding the antibiotic moxifloxacin to the usual TB drugs shortened the
time to cure to an estimated four months in a study in Brazil, Johns
Hopkins University scientists reported at an American Society for
Microbiology conference in Chicago.

A second study by Hopkins researchers cured mice of TB in 10 weeks
instead of the usual six months with moxifloxacin plus the TB drug
rifapentine at higher doses.

"It sounds fantastic," said Dr. Melvin Spigelman, research and
development director for the nonprofit Global Alliance for TB Drug
Development in New York. "The science is there" and just needs to be
verified in larger studies, he said. The group will launch a
2,400-patient study later this year.

Also on Tuesday, the Seattle-based Bill & Melinda Gates Foundation
announced its largest grants ever to fight TB?- $280 million for research
on vaccines, diagnostics and drugs.

"If everything goes well, it should be feasible to shorten treatment
time," possibly even to ultra-short regimens of two weeks to a month,
said Ken Duncan, the foundation's program director.

More than 8 million people worldwide develop TB each year and nearly 2
million die of it. The disease is mostly a problem in poor countries, but
the recent case of Andrew Speaker, an Atlanta attorney who created an
international health scare by traveling while he had a
multidrug-resistant strain of TB, shows the danger in the United States
as well.

Recently, a Mexican teenager was jailed in Georgia and threatened with
deportation after refusing to take his recommended nine months of TB
treatment. Similar cases have surfaced around the country.

Treatment now consists of three or four antibiotics taken daily for six
months or more. But half of patients do not take all their pills,
allowing resistant bacteria to grow and spread, said Dr. Jacques Grosset,
the Hopkins researcher who led the study of several hundred mice.

The Brazil study involved about 170 men and women in Rio de Janeiro who
had active TB. All were given three standard anti-TB drugs plus either
moxifloxacin or an older drug, ethambutol.

After two months, 85 percent of those on moxifloxacin tested negative for
the infection compared to 68 percent on ethambutol. The treatment
advantage showed up in as little as two weeks.

"Based on what we know, if you get that big a difference at two months,
you should be able to shorten the duration of treatment ... down to
four," said Dr. Richard Chaisson, director of TB research at Hopkins.

In a third study of about 400 TB patients throughout Africa, 60 percent
who received moxifloxacin plus three other drugs tested negative for TB
at two months versus 55 percent given isoniazid and the other medications.

The federal government paid for the studies, and Bayer Healthcare AG
donated moxifloxacin, which it sells as Avelox in the United States for
short-term use against pneumonia and other respiratory illnesses. The
pill costs $10 a day, but researchers said Bayer has promised to make it
available in poor countries for less if it is approved to treat TB.

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